منابع مشابه
Semaphorin signalling
Semaphorins are multifunctional proteins essential for embryonic development and for various physiological functions in the adult. These proteins interact with members of the plexin and neuropilin families of transmembrane receptors, leading to the activation of a diverse range of intracellular signalling events. A key characteristic of semaphorins is their ability to alter cytoskeletal dynamic...
متن کاملTyrosine phosphorylation in semaphorin signalling: shifting into overdrive.
The semaphorins constitute a large family of molecular signals with regulatory functions in neuronal development, angiogenesis, cancer progression and immune responses. Accumulating data indicate that semaphorins might trigger multiple signalling pathways, and mediate different and sometimes opposing effects, depending on the cellular context and the particular plexin-associated subunits of the...
متن کاملp190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Plexins are transmembrane receptors for semaphorins, guiding cell migration and axon extension. Plexin activation leads to the disassembly of integrin-based focal adhesive structures and to actin cytoskeleton remodelling and inhibition of cell migration; however, the underlying molecular mechanisms are unclear. We consistently observe a transient decrease of cellular RhoA-GTP levels upon plexin...
متن کاملRole of Robo1 receptor in semaphorin signalling system and cortical interneuron migration
work presented here in this thesis is my own. Where information has been derived from other sources, I confirm that it has been indicated clearly in the thesis. Abstract En route to the cerebral cortex, interneurons encounter the developing striatum and avoid it. It has been shown that these cells express neuropilin (Nrp) as well as PlexinA receptors, which allow these cells to respond to Sema3...
متن کاملLimk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium
En route to the neocortex, interneurons migrate around and avoid the developing striatum. This is due to the chemorepulsive cues of class 3 semaphorins (Sema3A and Sema3F) acting through neuropilin and plexin co-receptors expressed in interneurons. In a recent genetic screen aimed at identifying novel components that may play a role in interneuron migration, we identified LIM-kinase 2 (Limk2), ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.04.055